2024

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Genet G*, Genet N*, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. 2024 Mar 19;149(12):944-962. doi: 10.1161/CIRCULATIONAHA.122.062952. Epub 2023 Dec 21. PMID: 38126211; PMCID: PMC10954087.

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Horitani K*, Chavkin NW*, Arai Y, Wang Y, Ogawa H, Yura Y, Evans MA, Cochran J, Thel MC, Sano M, Miura-Yura E, Arai Y, Doviak H, Arnold AP, Hirschi KK, Sano S*, Walsh K. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. Nature Cardiovasc Res. 2024 Mar 8;3:343-355.

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Dunaway LS, Luse MA, Nyshadham S, Bulut G, Alencar GF, Chavkin NW, Cortese-Krott M, Hirschi KK, Isakson BE. Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium. Physiol Genomics. 2024 Feb 1;56(2):113-127. doi: 10.1152/physiolgenomics.00109.2023. Epub 2023 Nov 20. PMID: 37982169.

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2023

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Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575.

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Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K. Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans. Front Cardiovasc Med. 2023 Sep 19;10:1264479. doi: 10.3389/fcvm.2023.1264479. PMID: 37795485; PMCID: PMC10546194.

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Cochran J, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, Arai Y, Horitani K, Park E, Chavkin NW, Kour A, Sano S, Mahajan N, Evans M, Huba M, Naya NM, Sun H, Ban Y, Hirschi KK, Toldo S, Abbate A, Druley TE, Ruberg FL, Maurer MS, Ezekowitz JA, Dyck JRB, Walsh K. Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Sep 8. doi: 10.1161/CIRCULATIONAHA.123.064170. Epub ahead of print. PMID: 37681311.

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Wu Y, Paila U, Genet G, Hirschi KK. MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. Dev Cell. 2023 Jul 24;58(14):1237-1249.e5. doi: 10.1016/j.devcel.2023.05.007. Epub 2023 Jun 8. PMID: 37295435; PMCID: PMC10424725.

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Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK. Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. Life Sci Alliance. 2023 May 17;6(8):e202201685. doi: 10.26508/lsa.202201685. PMID: 37197981.

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Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 3:S0092-8674(23)00413-0. doi: 10.1016/j.cell.2023.04.017. Epub ahead of print. PMID: 37167971.

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Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE. Rational engineering of lung alveolar epithelium. NPJ Regen Med. 2023 Apr 28;8(1):22. doi: 10.1038/s41536-023-00295-2. PMID: 37117221; PMCID: PMC10147714.

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de Souza VBC, Jordan BT, Tseng E, Nelson EA, Hirschi KK, Sheynkman G, Robinson MD. Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data. Genome Biol. 2023 Apr 24;24(1):91. doi: 10.1186/s13059-023-02923-y. PMID: 37095564.

 

Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada H, Goldberg JS, Acharya BR, Bhatt N, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZ, Eichmann A, Thomas JL, ffrench-Constant C, Hirschi KK. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Reports. 2023 Apr 25;42(4):112371. doi: 10.1016/j.celrep.2023.112371.

 

Mehlferber MM, Jeffery ED, Saquing J, Jordan BT, Sheynkman L, Murali M, Genet G, Acharya BR, Hirschi KK, Sheynkman GM. Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics. RNA Biol. 2022 Jan;19(1):1228-1243. doi: 10.1080/15476286.2022.2141938. PMID: 36457147; PMCID: PMC9721438.

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2022

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Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba M, Sheynkman GM, Walsh K, Hirschi KK. Endothelial cell cycle state determines propensity for arterial-venous fate. Nat Commun. 2022 Oct 6;13(1):5891. doi: 10.1038/s41467-022-33324-7. PMID: 36202789.

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Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundström J, Yura Y, Kour A, Arai Y, Thel MC, Arai Y, Mychaleckyj JC, Hirschi KK, Forsberg LA, Walsh K. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science. 2022 Jul 15;377(6603):292-297. doi: 10.1126/science.abn3100. Epub 2022 Jul 14. PMID: 35857592; PMCID: PMC9437978.

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Coon BG, Timalsina S, Astone M, Zhuang ZW, Fang J, Han J, Themen J, Chung M, Yang-Klingler YJ, Jain M, Hirschi KK, Yamamato A, Trudeau LE, Santoro M, Schwartz MA. A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. J Cell Biol. 2022 Jul 4;221(7):e202109144. doi: 10.1083/jcb.202109144. Epub 2022 Jun 13. PMID: 35695893; PMCID: PMC9198948.

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Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol DN, Zhao Y, Chramiec A, Tagore S, Summers M, Stylianos S, Tamargo M, Lee BM, Halligan SP, Abaci EH, Guo Z, Jacków J, Pappalardo A, Shih J, Soni RK, Sonar S, German C, Christiano AM, Califano A, Hirschi KK, Chen CS, Przekwas A, Vunjak-Novakovic G. A multi-organ chip with matured tissue niches linked by vascular flow. Nat Biomed Eng. 2022 Apr;6(4):351-371. doi: 10.1038/s41551-022-00882-6. Epub 2022 Apr 27. PMID: 35478225; PMCID: PMC9250010.

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Aragon JW, Hirschi KK. Endothelial Cell Differentiation and Hemogenic Specification. Cold Spring Harb Perspect Med. 2022 Jul 29;12(7):a041164. doi: 10.1101/cshperspect.a041164. PMID: 35193895; PMCID: PMC9341460.

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Acharya BR*, Chavkin NW*, Hirschi KK. (2022) Developmental and Environmental Base of Endothelial Cell Diversity (Lineage, Epigenetics, Hemodynamics) Connection with Organogenesis. In Z. S. Galis (Ed.). The Vasculome: From Many, One (pp. 5-15). Elsevier, Inc.

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Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight. 2022 Feb 2;7(4):e156046. doi: 10.1172/jci.insight.156046. PMID: 35108221; PMCID: PMC8876496.

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2021

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Chavkin NW, Cain S, Walsh K, Hirschi KK. Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing. J Vis Exp. 2021 Oct 11;(176). doi: 10.3791/63133. PMID: 34694293.

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Genet N, Hirschi KK. Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Regen Med. 2021 Sep;16(9):861-870. doi: 10.2217/rme-2021-0022. Epub 2021 Sep 9. PMID: 34498495.

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Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K. The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. J Am Heart Assoc. 2021 Jul 6;10(13):e019904. doi: 10.1161/JAHA.120.019904. Epub 2021 Jun 22. PMID: 34155901; PMCID: PMC8403294.

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Nelson EA, Qiu J, Chavkin NW, Hirschi KK. Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells. J Vis Exp. 2021 Mar 31;(169). doi: 10.3791/62391. PMID: 33871448.

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Marziano C, Genet G, Hirschi KK. Vascular endothelial cell specification in health and disease. Angiogenesis. 2021 May;24(2):213-236. doi: 10.1007/s10456-021-09785-7. Epub 2021 Apr 12. PMID: 33844116; PMCID: PMC8205897.

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Wu Y, Hirschi KK. Tissue-Resident Macrophage Development and Function. Front Cell Dev Biol. 2021 Jan 8;8:617879. doi: 10.3389/fcell.2020.617879. PMID: 33490082; PMCID: PMC7820365.

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2020

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Kasper DM, Hintzen J, Wu Y, Ghersi JJ, Mandl HK, Salinas KE, Armero W, He Z, Sheng Y, Xie Y, Heindel DW, Park EJ, Sessa WC, Mahal LK, Lebrilla C, Hirschi KK, Nicoli S. The N-glycome regulates the endothelial-to-hematopoietic transition. Science. 2020 Dec 4;370(6521):1186-1191. doi: 10.1126/science.aaz2121. Epub 2020 Dec 3. PMID: 33273096; PMCID: PMC8312266.

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Qiu J, Nordling S, Vasavada HH, Butcher EC, Hirschi KK. Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Cell Rep. 2020 Dec 1;33(9):108465. doi: 10.1016/j.celrep.2020.108465. PMID: 33264627; PMCID: PMC8105879.

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Wu Y, Hirschi KK. Regulation of Hemogenic Endothelial Cell Development and Function. Annu Rev Physiol. 2021 Feb 10;83:17-37. doi: 10.1146/annurev-physiol-021119-034352. Epub 2020 Oct 9. PMID: 33035429.

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Chavkin NW, Walsh K, Hirschi KK. Isolation of Highly Purified and Viable Retinal Endothelial Cells. J Vasc Res. 2021;58(1):49-57. doi: 10.1159/000510533. Epub 2020 Oct 6. PMID: 33022674; PMCID: PMC7850292.

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Chavkin NW, Hirschi KK. Single Cell Analysis in Vascular Biology. Front Cardiovasc Med. 2020 Mar 31;7:42. doi: 10.3389/fcvm.2020.00042. PMID: 32296715; PMCID: PMC7137757.

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Wang Y, Sano S, Yura Y, Ke Z, Sano M, Oshima K, Ogawa H, Horitani K, Min KD, Miura-Yura E, Kour A, Evans MA, Zuriaga MA, Hirschi KK, Fuster JJ, Pietras EM, Walsh K. Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. JCI Insight. 2020 Mar 26;5(6):e135204. doi: 10.1172/jci.insight.135204. PMID: 32154790; PMCID: PMC7213793.

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